Oh, the joys of acne. While most people treat their acne with over the counter acne creams and astringents, those who see a healthcare professional for their acne will require something much stronger. Standard of care currently is a retinoic acid derivative and antibiotics. So how do we prevent antibiotic resistance in these patients who are on them chronically? Benzoyl peroxide. Yes, the tried and true towel-bleaching ingredient in half of all OTC acne preparations has been shown to help curb antibiotic resistance in those on antibiotics for acne.